Template-type: ReDIF-Paper 1.0
Author-Name: Iris Mangas
Author-Name: Antonio F. Hernandez
Author-Name: Kevin Crofton
Author-Name: Mary Gilbert
Author-Name: Martin Paparella
Author-Name: Anna Price
Author-Name: Tim Shafer
Author-Name: Laura Martino
Author-Name: Martina Panzarea
Author-Name: Andrea Terron
Author-Workplace-Name: European Food Safety Authority
Title: Adverse Outcome Pathway on Binding to voltage gate sodium channels during development leading to cognitive impairment
Abstract: This adverse outcome pathway links the binding of xenobiotics to voltage gate sodium channels (VGSCs) during development, to cognitive impairment. The binding of xenobiotics to VGSCs may lead to disruption of action potential generation and consequently to an alteration in neurotransmission. Neurotransmitter release is essential for neural activity and neural activity is critical for normal brain development. Therefore, chemicals that bind with VGSCs have the potential to cause adverse effects on the developing brain. This AOP focuses on the hippocampus because of its well-known ties to cognition, and downstream outcome of concern for many chemical exposures. This AOP is referred to as AOP 442 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki): https://aopwiki.org.
Creation-Date: 2025-06-26
Number: 36
Handle: RePEc:oec:envaad:36-EN